Evaluasi Dosis Efektif Boron Neutron Capture Therapy (BNCT) Glioblastoma Multiforme Menggunakan Simulasi Monte Carlo

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DOI:

https://doi.org/10.25077/jfu.12.4.683-689.2023

Abstract

Glioblastoma multiforme merupakan kanker otak stadium IV yang sangat sulit diobati dan umumnya terjadi pada hemisfer serebrum otak. Terapi BNCT telah dikembangkan untuk pengobatan glioblastoma yang lebih aman, namun hamburan neutron dan foton gamma yang berasal dari terapi pada organ at risk ini perlu dievaluasi menggunakan simulasi. Metode yang dilakukan dengan mensimulasikan phantom ORNL-MIRD bagian kepala dan leher menggunakan program MCNPX. Arah penyinaran radiasi terhadap pasien dibuat menjadi dua arah yaitu RLAT dan TOP. Perhitungan dosis dalam BNCT dilakukan dengan mencari nilai dosis serap, dosis ekuivalen, dan dosis efektif. Dosis efektif dianalisis menggunakan ICRP publikasi 60 dan 103. Berdasarkan perhitungan dosis serap, arah penyinaran yang paling efektif adalah arah penyinaran TOP, dengan persentase dosis serap pada organ at risk relatif aman terutama pada organ tiroid, dan nilai pada organ cranium, otak, tiroid, dan kulit berturut-turut sebesar 11,4%, 10,15%, 0,002%, dan 6,4%. Nilai dosis efektif pada ICRP 60 dan 103 bernilai sama pada organ cranium dan kulit. Namun, pada organ tiroid, nilai dosis efektif dengan ICRP 103 lebih rendah dibandingkan ICRP 60. Hal ini menandakan berkurangnya resiko untuk penyakit terwaris pada tiroid, dan pada organ otak hanya dihitung menggunakan ICRP 103

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Published

2023-10-09

How to Cite

Handayani, L. T., Budi, W. S., & Arianto, F. (2023). Evaluasi Dosis Efektif Boron Neutron Capture Therapy (BNCT) Glioblastoma Multiforme Menggunakan Simulasi Monte Carlo. Jurnal Fisika Unand, 12(4), 683–689. https://doi.org/10.25077/jfu.12.4.683-689.2023

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Vol. 12 No. 4 (2023)

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